A Paramagnetic CEST Agent for Imaging Glucose by MRI
2003; American Chemical Society; Volume: 125; Issue: 50 Linguagem: Inglês
10.1021/ja038345f
ISSN1943-2984
AutoresShanrong Zhang, R. Trokowski, A. Dean Sherry,
Tópico(s)Electron Spin Resonance Studies
ResumoThe europium(III) complex of a DOTA−tetraamide ligand (DOTA = 1,4,7,10-tetraazacyclododecane-N,N',N' ',N' ''-tetraacetic acids) containing two phenyl boronate pendent arms binds glucose reversibly with an association constant of 383 M-1 at pH 7. Glucose binding results in slowing of water exchange between a single Eu(III)-bound water molecule and bulk water, and this can be imaged by MRI using chemical exchange saturation transfer (CEST) imaging sequence. This metabolite-responsive paramagnetic CEST agent responds to changes in glucose over the physiologically important range (0−20 mM), and thus it offers the possibility of high-sensitivity MR imaging glucose in tissues using bulk water protons as antenna.
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