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Controlling low rates of cell differentiation through noise and ultrahigh feedback

2014; American Association for the Advancement of Science; Volume: 344; Issue: 6190 Linguagem: Inglês

10.1126/science.1252079

1095-9203

Robert Ahrends, Asuka Ota, Kyle M. Kovary, Takamasa Kudo, Byung Ouk Park, Mary N. Teruel,

Receptor Mechanisms and Signaling

Cell fate control—a numbers game Precursor cells in adult mammalian tissues differentiate at very low rates; for example, only 10% of fat cells are replaced per year. If all precursor cells responded to the same threshold of stimulus, these low rates would not be possible. Noise in the system (variability in the abundance of key proteins in different cells) could allow only a few cells to differentiate, but then such variability would allow dedifferentiation as well, which is not observed. Ahrends et al. used computational modeling and protein measurements in single cells to show that multiple feedback loops in the regulatory circuits, along with noise, can allow both stable and infrequent differentiation. Science , this issue p. 1384