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Evidence for the presence of angiotensin II-type 1 receptors in brain

1990; Elsevier BV; Volume: 25; Issue: 3 Linguagem: Inglês

10.1016/0361-9230(90)90226-p

1873-2747

James K. Wamsley, William F. Herblin, Mario E. Alburges, Mary Hunt,

Neuropeptides and Animal Physiology

Angiotensin II receptor subtypes have been localized in brain by using a novel nonpeptide AII-type 1 receptor antagonist to compete with [125I]AII binding in an autoradiographic study. These data contrast with results obtained using the AII-type 2 antagonist PD123177. Both receptor subtypes appear to exist in the brain, but the type 1 receptor predominates in the small regions of brain where AII binding is highly concentrated. DUP 753 may have a central action involved in its unique antihypertensive effect.