ATRP Synthesis of Amphiphilic Random, Gradient, and Block Copolymers of 2-(Dimethylamino)ethyl Methacrylate and n -Butyl Methacrylate in Aqueous Media
2003; American Chemical Society; Volume: 4; Issue: 5 Linguagem: Inglês
10.1021/bm034126a
ISSN1526-4602
AutoresSang Beom Lee, Alan J. Russell, Krzysztof Matyjaszewski,
Tópico(s)Radioactive element chemistry and processing
ResumoAmphiphilic random, gradient, and block copolymers of 2-(dimethylamino)ethyl methacrylate (DMAEMA) and n-butyl methacrylate (BMA) were synthesized by atom transfer radical polymerization (ATRP) in water/2-propanol mixtures using a methoxy-poly(ethylene glycol) (MPEG) (Mn = 2000) macroinitiator. Kinetic studies indicate that the copolymerization is well controlled with molecular weights increasing linearly with conversion. Copolymers with molecular weights up to Mn = 34 000 and low polydispersities (Mw/Mn = 1.11−1.47) were prepared. The reactivity ratios were calculated for the copolymerizations catalyzed by CuBr/bpy, (rDMAEMA = 1.07, rBMA = 1.24). The thermosensitivity and aggregation properties of the random, gradient, and block copolymers significantly depended on the architecture of the copolymers. The lower critical solution temperature of MPEG-b-PDMAEMA84 was 38 °C (5 wt % in water).
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