Treatment of Infections in Man With Cephalothin
1964; American Medical Association; Volume: 189; Issue: 11 Linguagem: Inglês
10.1001/jama.1964.03070110031006
ISSN1538-3598
AutoresLouis Weinstein, Kenneth Kaplan, Te‐Wen Chang,
Tópico(s)Antibiotic Resistance in Bacteria
ResumoCephalothin, a semisynthetic derivative of cephalosporanic acid, was used successfully to treat 77 of 80 infections. Therapy was successful against Staphylococcus aureus, Streptococcus, Diplococcus pneumoniae, Escherichia coli, Clostridium perfringens, Aerobacter aerogenes , mixed Proteus mirabilis, Str faecalis , and mixed Staph aureus and group A Str pyogenes infections. Miliary tuberculosis, Hemophilus influenzae meningitis, and vaccinia failed to respond. No cross-sensitivity between cephalothin and penicillin could be documented, suggesting that cephalothin is an effective parenteral antibacterial agent for infections produced by penicillin G-sensitive and resistant staphylococci, pneumococci, streptococci, possibly C1 perfringens , and selected gram-negative enteric bacteria.
Referência(s)