A breakthrough method for the accurate addition of reagents in multi-step segmented flow processing
2011; Royal Society of Chemistry; Volume: 2; Issue: 4 Linguagem: Inglês
10.1039/c0sc00603c
ISSN2041-6539
AutoresHeiko Lange, Catherine F. Carter, Mark D. Hopkin, Adrian Burke, Jon G. Goode, Ian R. Baxendale, Steven V. Ley,
Tópico(s)Analytical Chemistry and Chromatography
ResumoIn order to use segmented chemical flow processing in more complex reaction sequences, a method has been developed to precisely control the addition of reagent streams during multi-step operations. Using in-line infra-red monitoring with a new LabVIEW software application, it is possible to control additional pumps to dispense further reagents in real time based upon the concentration of reaction intermediates. This enables precise mixing with perfect timing thus greatly increasing product quality and enabling segmented chemical flow processing to be used in extended reaction sequences.
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