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Nitric oxide from L-arginine stimulates the soluble guanylate cyclase in adrenal glands

1989; Elsevier BV; Volume: 165; Issue: 2 Linguagem: Inglês

10.1016/s0006-291x(89)80037-3

1090-2104

Miriam Palacios‐Callender, Richard G. Knowles, Richard Palmer, Salvador Moncada,

Neuropeptides and Animal Physiology

The formation of nitric oxide (NO) by an L-arginine:NO synthase and its stimulation of the soluble guanylate cyclase was studied in rat whole adrenal and bovine cortex and medulla cytosol. In the presence of L-arginine, the stimulation of soluble guanylate cyclase was accompanied by the formation of citrulline and NO2−, formed from NO. The NO synthase was NADPH- and Ca2+- dependent and was inhibited by several L-arginine analogues. These results indicate that rat and bovine adrenal cytosol contains an L-arginine:NO synthase.