Stress-induced synthesis of melatonin: Possible involvement of the endogenous monoamine oxidase inhibitor (tribulin)
1985; Elsevier BV; Volume: 37; Issue: 18 Linguagem: Inglês
10.1016/0024-3205(85)90303-0
ISSN1879-0631
AutoresGregory F. Oxenkrug, Iain M. McIntyre,
Tópico(s)Photoreceptor and optogenetics research
ResumoCold-restrained stress increased rat pineal melatonin and N-acetylserotonin content. This effect was partially prevented by lorazepam. Serotonergic turnover (ratio of 5-hydroxyindole acetic acid to serotonin) was significantly decreased in stressed but not in stressed rats pretreated with lorazepam, suggesting stress-induced inhibition of monoamine oxidase (MAO). Literature data indicate that the same type of stress increases the production of the endogenous MAO inhibitor. The implication of stress-induced MAO inhibition on melatonin synthesis in anxiety and drug withdrawal is discussed.
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