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Reflectance confocal microscopy of pigmented basal cell carcinoma

2006; Elsevier BV; Volume: 54; Issue: 4 Linguagem: Inglês

10.1016/j.jaad.2005.11.1096

1097-6787

Anna Liza C. Agero, Klaus J. Busam, Cristiane Benvenuto-Andrade, Alon Scope, Melissa Gill, Ashfaq A. Marghoob, Salvador González, Allan C. Halpern,

Optical Coherence Tomography Applications

Background Reflectance confocal microscopy (RCM) is a high-resolution imaging tool for in vivo noninvasive evaluation of skin lesions. Objective We sought to describe the relevant RCM features for pigmented basal cell carcinoma (BCC). Methods Pigmented skin lesions with a differential diagnosis of pigmented BCC were imaged using dermoscopy and RCM, followed by excision for histologic analysis. Results RCM demonstrated aggregations of tightly packed cells with palisading, forming cordlike structures and nodules with irregular borders and variable brightness; these represented nests of pigmented basaloid tumor cells on histopathology, and blue-gray ovoid areas on dermoscopy. These tumor nests were associated with bright dendritic structures, identified histologically as either melanocytes or Langerhans cells, together with numerous bright oval to stellate-shaped structures with indistinct borders representing melanophages, and with highly refractile granules of melanin. Limitations The pigmented BCCs imaged in this study were predominantly nodular; a different set or additional criteria may be necessary for detection of infiltrative and metatypical BCCs. Conclusion RCM may permit in vivo diagnosis of pigmented BCC. Reflectance confocal microscopy (RCM) is a high-resolution imaging tool for in vivo noninvasive evaluation of skin lesions. We sought to describe the relevant RCM features for pigmented basal cell carcinoma (BCC). Pigmented skin lesions with a differential diagnosis of pigmented BCC were imaged using dermoscopy and RCM, followed by excision for histologic analysis. RCM demonstrated aggregations of tightly packed cells with palisading, forming cordlike structures and nodules with irregular borders and variable brightness; these represented nests of pigmented basaloid tumor cells on histopathology, and blue-gray ovoid areas on dermoscopy. These tumor nests were associated with bright dendritic structures, identified histologically as either melanocytes or Langerhans cells, together with numerous bright oval to stellate-shaped structures with indistinct borders representing melanophages, and with highly refractile granules of melanin. The pigmented BCCs imaged in this study were predominantly nodular; a different set or additional criteria may be necessary for detection of infiltrative and metatypical BCCs. RCM may permit in vivo diagnosis of pigmented BCC.