Cytotoxic Triterpene Acids from the Peruvian Medicinal Plant Polylepis racemosa
2000; Thieme Medical Publishers (Germany); Volume: 66; Issue: 5 Linguagem: Inglês
10.1055/s-2000-8583
ISSN1439-0221
AutoresCatherine Neto, Abraham Vaisberg, Bing‐Nan Zhou, David G. I. Kingston, Gerald B. Hammond,
Tópico(s)Essential Oils and Antimicrobial Activity
ResumoCytotoxicity-guided fractionation of the bark and stem extract of Polylepis racemosa led to the identification of ursolic acid, pomolic acid, 3-O-acetylpomolic acid, and 2-oxopomolic acid. Pomolic acid was the most cytotoxic component, and was specific for M-14 melanoma and ME180 cervical carcinoma, with GI50 values of 6.9 and 8.3 micrograms/mL respectively.
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