Metabolism of the carcinogenic bifunctional olefin oxide, 4-vinyl-1-cyclohexene dioxide, by hepatic microsomes
1976; Elsevier BV; Volume: 25; Issue: 5 Linguagem: Inglês
10.1016/0006-2952(76)90395-6
ISSN1873-2968
AutoresTadashi Watabe, Tadashi Sawahata,
Tópico(s)Diet, Metabolism, and Disease
ResumoWhen 4-vinylcyclohexene (VCHE) and 4-vinylcyclohexene monoxide (VCM) were administered to mice at 500 mg/kg, cytochrome P-450, cytochrome b5, NADPH-cytochrome c reductase and aminopyrine-N-demethylase and epoxide hydrolase were induced. Doses of 500 mg/kg of VCHE, VCM and 4-vinylcyclohexene diepoxide depleted rapidly hepatic reduced glutathione levels suggesting that glutathione is probably involved in the metabolism of VCHE.
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