The α-effect in iminium ion catalysis
2005; Elsevier BV; Volume: 62; Issue: 2-3 Linguagem: Inglês
10.1016/j.tet.2005.08.110
ISSN1464-5416
AutoresJulie L. Cavill, Richard L. Elliott, Gareth J. S. Evans, Ian L. Jones, James A. Platts, Antonio M. Ruda, Nicholas C. O. Tomkinson,
Tópico(s)Asymmetric Hydrogenation and Catalysis
ResumoThe α-effect can be used as an effective means to promote iminium ion catalysed transformations, providing acyclic scaffolds to aid in catalyst design. A thorough investigation of the structure–activity relationship of the catalyst architecture reveals optimal substituents of a disubstituted carbamate and a secondary alkyl group around a hydrazine scaffold. Molecular modelling investigations provide a mechanistic rationale to the results observed.
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