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No association with germline T cell receptor β-chain gene alleles or haplotypes in Swedish patients with multiple sclerosis

1991; Elsevier BV; Volume: 32; Issue: 2 Linguagem: Inglês

10.1016/0165-5728(91)90006-s

1872-8421

Jan Hillert, Chunmao Leng, Olle Olerup,

Immunotherapy and Immune Responses

Multiple sclerosis (MS) has been reported to be associated with restriction fragment length polymorphism (RFLP)-defined alleles of the T cell receptor (TcR) α- and β-chain genes. One hundred patients with MS, 23 with primarily chronic progressive MS and 77 with relapsing/remmitting MS, as well as 100 controls were investigated with RFLP analysis of the Vβ8, Vβ11 and Cβ TCR gene segments. No association was found with allelic patterns or, contrary to a previous report (Beall et al. (1989) J. Neuroimmunol. 21, 59–66), TcR β-chain gene haplotypes. Subgrouping of patients according to clinical form of disease or MS-associated HLA class II alleles also failed to show associations to TcR β-chain RFLPs. Thus, our results fail to confirm that TcR β-chain gene haplotypes confer susceptibility to MS.