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BIBTEX RIS

Clinicopathological characteristics and perineural invasion in adenoid cystic carcinoma: a systematic review

2015; Elsevier BV; Volume: 81; Issue: 3 Linguagem: Inglês

10.1016/j.bjorl.2014.07.016

1808-8694

Afonso Nóbrega Dantas, Éverton Freitas de Morais, Rômulo Augusto de Paiva Macêdo, João Maria de Lima Tinôco, Maria de Lourdes Silva de Arruda Morais,

Oral and Maxillofacial Pathology

Adenoid cystic carcinoma is the most frequent malignant tumor of the submandibular gland and the minor salivary glands. It is a malignant neoplasm that, despite its slow growth, shows an unfavorable prognosis.The aim of this study was to perform a systematic review of the literature on Adenoid cystic carcinoma in the head and neck region and its clinicopathological characteristics, with emphasis on the perineural invasion capacity of the tumor.A systematic search of articles published between January 2000 and January 2014 was performed in the PubMed/MEDLINE, SciELO, Science Direct, and Scopus databases.Nine articles were selected for this systematic review. These demonstrated that the female gender was more often affected and that malignant tumors showed a high rate of distant metastasis, recurrence, and a low survival rate. The presence of perineural invasion ranged from 29.4% to 62.5% and was associated with local tumor recurrence.Adenoid cystic carcinoma is commonly characterized by the presence of pain, high rate of recurrence, metastasis, and a low survival rate. Reporting studies with patient follow-up is of utmost importance for a better clinical-pathological understanding and to improve the prognosis of this pathology.