Artigo Acesso aberto Revisado por pares

Immunohistochemical study of carcinoembryonic antigen in patients with colorectal cancer. Correlation with plasma carcinoembryonic antigen levels

1985; Wiley; Volume: 55; Issue: 1 Linguagem: Inglês

10.1002/1097-0142(19850101)55

ISSN

1097-0142

Autores

Yoshinori Hamada, Manabu Yamamura, K Hioki, Masakatsu Yamamoto, Hiroshi Nagura, Keiichi Watanabe,

Tópico(s)

Cancer Immunotherapy and Biomarkers

Resumo

CancerVolume 55, Issue 1 p. 136-141 ArticleFree Access Immunohistochemical study of carcinoembryonic antigen in patients with colorectal cancer. Correlation with plasma carcinoembryonic antigen levels† Yoshinori Hamada MD, Corresponding Author Yoshinori Hamada MD Department of Surgery, Kansai Medical University, Osaka, JapanYoshinori Hamada, MD, Department of Surgery, Kansai Medical University, Moriguchi, Osaka, Japan===Search for more papers by this authorManabu Yamamura MD, Manabu Yamamura MD Department of Surgery, Kansai Medical University, Osaka, JapanSearch for more papers by this authorKohshiro Hioki MD, Kohshiro Hioki MD Department of Surgery, Kansai Medical University, Osaka, JapanSearch for more papers by this authorMasakatsu Yamamoto MD, Masakatsu Yamamoto MD Department of Surgery, Kansai Medical University, Osaka, Japan Professor.Search for more papers by this authorHiroshi Nagura MD, Hiroshi Nagura MD Department of Pathology, Tokai University School of Medicine, Kanagawa, Japan Associate Professor.Search for more papers by this authorKeiichi Watanabe MD, Keiichi Watanabe MD Department of Pathology, Tokai University School of Medicine, Kanagawa, Japan Professor.Search for more papers by this author Yoshinori Hamada MD, Corresponding Author Yoshinori Hamada MD Department of Surgery, Kansai Medical University, Osaka, JapanYoshinori Hamada, MD, Department of Surgery, Kansai Medical University, Moriguchi, Osaka, Japan===Search for more papers by this authorManabu Yamamura MD, Manabu Yamamura MD Department of Surgery, Kansai Medical University, Osaka, JapanSearch for more papers by this authorKohshiro Hioki MD, Kohshiro Hioki MD Department of Surgery, Kansai Medical University, Osaka, JapanSearch for more papers by this authorMasakatsu Yamamoto MD, Masakatsu Yamamoto MD Department of Surgery, Kansai Medical University, Osaka, Japan Professor.Search for more papers by this authorHiroshi Nagura MD, Hiroshi Nagura MD Department of Pathology, Tokai University School of Medicine, Kanagawa, Japan Associate Professor.Search for more papers by this authorKeiichi Watanabe MD, Keiichi Watanabe MD Department of Pathology, Tokai University School of Medicine, Kanagawa, Japan Professor.Search for more papers by this author First published: 1 January 1985 https://doi.org/10.1002/1097-0142(19850101)55:1 3.0.CO;2-PCitations: 100 † Presented in part at the 13th International Cancer Congress, Seattle, September 10, 1982. AboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onEmailFacebookTwitterLinkedInRedditWechat Abstract Using peroxidase-antiperoxidase (PAP) method, carcinoembryonic antigen (CEA) was demonstrated in conventionally processed colorectal cancer tissues. A new immunohistochemical grading for colorectal cancers based on the mode of the localization was made in an attempt to clarify the factors responsible for elevation of plasma CEA levels in colorectal cancer patients. Most of the patients with well differentiated adenocarcinoma, in which CEA was densely distributed along the apical surface but only rarely present along the basolateral surfaces of the carcinoma cells, had very low levels of plasma CEA, whereas all patients showing CEA distribution in the stroma as well as over the entire surfaces of the cancer cells and their cytoplasm showed high plasma CEA levels. In addition, there was a good correlation between the grading and presence of the blood vessel and lymphatic invasions. Thus, the appearance of CEA in the surrounding stroma, due to abnormal distribution of CEA on the basolateral plasma membrane of cancer cells, may play a significant role in the elevation of plasma CEA levels in colorectal cancer patients. References 1 Gold P, Freedman SO. Demonstration of tumor-specific antigens in human colonic carcinomata by immunological tolerance and absorption techniques. 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