Lovastatin Inhibits Gallstone Formation in the Cholesterol-fed Prairie Dog
1991; Lippincott Williams & Wilkins; Volume: 214; Issue: 2 Linguagem: Inglês
10.1097/00000658-199108000-00009
ISSN1528-1140
AutoresKimberly D. Saunders, JOE A. GATES, Mohammad Z. Abedin, Sheila Rege, Sarkis Festekdjian, WARREN HOWARD, Joel J. Roslyn,
Tópico(s)Gout, Hyperuricemia, Uric Acid
ResumoThe efficacy of lovastatin, an inhibitor of hepatic cholesterol synthesis in the prevention of cholesterol gallstone formation, was evaluated in the prairie dog model. Two groups of animals were maintained on either nonlithogenic or 1.2% cholesterol-enriched chow for 21 days. Seven of the animals in each group received lovastatin, and the remaining six received only distilled water. All of the cholesterol-fed/water-treated animals had crystals and 83% had gallstones, but none of the cholesterolfed/lovasta tin-treated animals had gallstones and only three had microscopic crystals. These data indicate that lovastatin inhibits cholesterol gallstone formation in a diet-induced model of gallstone disease.
Referência(s)