Portal de Periódicos da CAPES

Molecular cloning of the gene encoding the bovine brain ribonucelase and its expression in different regions of the brain

1991; Oxford University Press; Volume: 19; Issue: 23 Linguagem: Inglês

10.1093/nar/19.23.6469

1362-4962

Maurizio Sasso, Antonella Carsana, Elena Confalone, Cristina Cosi, Salvatore Sorrentino, Mariapia Viola, Mark O. Palmier, Edda Russo, Adriana Furia,

Enzyme Structure and Function

In this paper we report the molecular cloning of the gene encoding the bovine brain ribonuclease. The nucleotide sequence determined in this work shows a high degree of identity to the homologous gene encoding the bovine pancreatic ribonuclease. Processing of the primary transcripts of these genes also follows a similar pathway, splicing of the unique intron in the 5′ untranslated region occurs at corresponding positions. Expression of the bovine brain ribonuclease gene can be detected both at the transcriptional and translational levels in all the regions of the brain examined.