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5-Arylazoniumuracil dibromoaurates(I): X-ray crystal structure of bis(6-amino-1,3-dimethyl-5-phenylazoniumuracil) dibromoaurate monobromide monohydrate, (DZH2)2(AuBr2)Br•H2O, and growth inhibition of HeLa cells

1989; Elsevier BV; Volume: 161; Issue: 2 Linguagem: Inglês

10.1016/s0020-1693(00)83093-5

1873-3255

José Suárez‐Varela, Jean-Pierre Legros, Jean Galy, Enrique Colacio, José Ruiz, J. de D. López-González, Paula Leon, Rosario Perona,

Lanthanide and Transition Metal Complexes

The preparation of a series of gold(I) compounds of general formulae (LH2)(AuBr2) and (LH2)2- (AuBr2)Br (LH2+: 5-arylazoniumuracil cations) is described. The crystal structure of (DZH2)2(AuBr2)- Br·H2O (DZH2+ 6-amino-1,3-dimethyl-5-phenylazoniumuracil cation) was determined. The crystals are triclinic; space group P1; a=12.188(1), b = 17.404(2), c = 7.764(1) Å, α = 99.79(1), β = 99.45(1), γ = 86.94(1)°; Z = 2; R = 0.030 for 3593 observed reflections and 310 variable parameters. The structure is ionic, the asymmetric unit contains one AuBr2− anion, two crystallographically independent DZH2+ cations, one isolated Br− anion and one molecule of water of crystallization. In each DZH cation the additional proton is bonded to a nitrogen atom of the azo group. The growth inhibition of HeLa cells by these bromogold(I) salts has been tested.