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Voltage-dependent ion channel formation by rigid rod-shaped polyols in planar lipid bilayers

1998; Elsevier BV; Volume: 8; Issue: 19 Linguagem: Inglês

10.1016/s0960-894x(98)00481-8

1464-3405

Naomi Sakai, Chiyou Ni, Sergey M. Bezrukov, Stefan Matile,

Conducting polymers and applications

In this Letter, we describe the appearance of large, voltage-dependent currents in BLM induced by rigid rodshaped polyols that function without charge and permanent dipole moment. The capacity of these symmetrical, nonpeptide models to form either short-living nanopores or small ion channels is shown to depend critically on the length of rigid-rod scaffold as well as the nature of the lateral side chains.