Produção Nacional
Revisado por pares
Síntese de beta-N-acetilglicosaminídeos de arila modificados em C-6 como potenciais agentes antimicrobianos
2008; Brazilian Chemical Society; Volume: 31; Issue: 2 Linguagem: Inglês
10.1590/s0100-40422008000200026
ISSN1678-7064
AutoresRozângela Magalhães Manfrini, José Dias de Souza Filho, Rute C. Figueiredo, Allison Fabiano D'Angelis, Maria Auxiliadôra Fontes Prado, Elzíria de Aguiar Nunan, Gabriela Aires Martins, Ricardo José Alves,
Tópico(s)Plant tissue culture and regeneration
ResumoWe report herein the synthesis of aryl β-N-acetylglucosaminides containing azido, amino and acetamido groups at C-6 as potential antimicrobial agents.It was expected that these compounds could interfere with the biosynthesis and/or biotransformation of Nacetylglucosamine in fungi and bacteria.None of the compounds showed antimicrobial activity against bacteria (Bacillus subtilis, Micrococcus luteus, Staphylococcus aureus, Escherichia coli and Pseudomonas aeruginosa), filamentous fungus (Aspergillus niger) and yeasts (Saccharomyces cerevisae, Candida albicans and Candida tropicallis), at the concentration of 1 mg/mL in agar diffusion assay.
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