Produção Nacional
Revisado por pares
Correlation between FLT3–ITD status and clinical, cellular and molecular profiles in promyelocytic acute leukemias
2014; Elsevier BV; Volume: 39; Issue: 2 Linguagem: Inglês
10.1016/j.leukres.2014.11.010
ISSN1873-5835
AutoresCarolina Pereira de Souza Melo, Catharina Brant Campos, Álvaro Pimenta Dutra, Joaquim Caetano de Aguirre Neto, Alexandre José Silva Fenelon, Abrahão Hallack Neto, Edna Kakitani Carbone, Mara Albonei Dudeque Pianovski, Alessandro Clayton de Souza Ferreira, Juliana Godoy Assumpção,
Tópico(s)Bone and Joint Diseases
ResumoInternal tandem duplications (ITD) of FLT3 gene occur in about a third of acute promyelocytic leukemias (APL). We investigated the patterns of blood count, surface antigen, expression, chromosome aberrations, PML–RARa isoform, gene expression profile (GEP) and survival in 34 APL patients according to FLT3–ITD status. 97% had a t(15;17) and all of them carried PML–RARa gene fusion, 8 (23.5%) had a FLT3–ITD mutation. Presence of ITD was associated with higher Hb and WBC levels, bcr3 isoform, CD34 expression, CD2 or CD2/CD34 expression. In a multivariate analysis, Hb > 9.6 g/dL and WBC ≥ 20 × 109/L were important factors for predicting ITD presence. GEP showed that FLT3–ITD carriers clustered separately, even when as few as 5 genes were considered. This study provides further evidence that FLT3–ITDs carriers constitute a biologically distinct group of APL patients.
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