Novel function of transthyretin in pancreatic alpha cells
2012; Wiley; Volume: 586; Issue: 23 Linguagem: Inglês
10.1016/j.febslet.2012.10.025
ISSN1873-3468
AutoresYu Su, Hirofumi Jono, Yohei Misumi, Takafumi Senokuchi, Jianying Guo, Mitsuharu Ueda, Satoru Shinriki, Masayoshi Tasaki, Makoto Shono, Konen Obayashi, Kazuya Yamagata, Eiichi Araki, Yukio Ando,
Tópico(s)Metabolism, Diabetes, and Cancer
ResumoAlthough transthyretin (TTR) is expressed in pancreatic alpha (glucagon) cells in the islets of Langerhans, the function of TTR in pancreatic alpha cells remains unknown. In this study, by using TTR knockout (TTR KO) mice, we determined the novel role of TTR in glucose homeostasis. We demonstrated that TTR KO mice evidenced impaired recovery of blood glucose and glucagon levels. Lack of TTR induced significantly lower levels of glucagon in the islets of Langerhans. These results suggest that TTR expressed in pancreatic alpha cells may play important roles in glucose homeostasis via regulating the expression of glucagon.
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