Portal de Periódicos da CAPES

Malignancies in Pemphigus and Pemphigoid Diseases

2015; Elsevier BV; Volume: 135; Issue: 5 Linguagem: Inglês

10.1038/jid.2014.547

1523-1747

Franziska Schulze, Kathrin Neumann, Andreas Recke, Detlef Zillikens, Roland Linder, Enno Schmidt,

Platelet Disorders and Treatments

Pemphigus and pemphigoid diseases comprise a heterogeneous group of diseases that are immunopathologically characterized by autoantibodies against structural proteins of the desmosome and dermo–epidermal junction, respectively. The clinical picture typically shows blisters and erosions on the skin and/or surface-close mucous membranes (Stanley and Amagai, 2006; Schmidt and Zillikens, 2013). Bullous pemphigoid (BP) is the most frequent of these diseases with a disease onset in the late seventies and an incidence of 150–300/millions/year in the population of 80 years and older (Langan et al.