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Stimulating Effect of Fructose 1-6 Diphosphate on the Phagocytic Function of Rat RES and on Human Leukocyte Carbohydrate Metabolism

1985; Elsevier BV; Volume: 290; Issue: 1 Linguagem: Inglês

10.1097/00000441-198507000-00002

1538-2990

Angel K. Markov, Nicole C. Oglethorpe, Joe Terry, James B. Grogan, Harper K. Hellems,

Cancer, Hypoxia, and Metabolism

The phagocytic behavior of the reticuloendothelial system in the rat was assessed by a quantitative technique following fructose-1,6-diphosphate (FDP) administration. In addition, the effect of FDP on the carbohydrate metabolism of human leukocytes was investigated. The rate of colloidal carbon clearance from the blood was increased significantly in the FDP-treated rats as compared to dextrose and saline controls (p < 0.001). FDP also attenuated the hepatic decrease of ATP (p < 0.005) and creatine phosphate (p < 0.005) that has been observed after intravenous administration of colloidal carbon. Carbohydrate metabolism in human leukocytes was enhanced by FDP, with a concomitant increase in ATP content (p < 0.001). Experimental evidence suggests that FDP intervenes in the Embden-Meyerhof pathway both as a metabolic regulator and as a high energy substrate. These properties of FDP in stimulating the carbohydrate metabolism have recently been described in man.