Portal de Periódicos da CAPES

SECOND DOROTHY S. RUSSELL MEMORIAL LECTURE THE NEUROPATHOLOGY OF ALZHEIMER'S DISEASE–ISSUES IN NEED OF RESOLUTION*

1989; Wiley; Volume: 15; Issue: 6 Linguagem: Inglês

10.1111/j.1365-2990.1989.tb01250.x

1365-2990

B. E. Tomlinson,

Medical and Biological Sciences

Neuropathology and Applied NeurobiologyVolume 15, Issue 6 p. 491-512 SECOND DOROTHY S. RUSSELL MEMORIAL LECTURE THE NEUROPATHOLOGY OF ALZHEIMER'S DISEASE–ISSUES IN NEED OF RESOLUTION* B. E. TOMLINSON, Corresponding Author B. E. TOMLINSON Neuropathology, Newcastle General Hospital, Newcastle upon Tyne, UK†Northern Regional Health Authority, Benfield Road, Newcastle upon Tyne NE6 4PY, UK.Search for more papers by this author B. E. TOMLINSON, Corresponding Author B. E. TOMLINSON Neuropathology, Newcastle General Hospital, Newcastle upon Tyne, UK†Northern Regional Health Authority, Benfield Road, Newcastle upon Tyne NE6 4PY, UK.Search for more papers by this author First published: December 1989 https://doi.org/10.1111/j.1365-2990.1989.tb01250.xCitations: 21 † *Delivered to the British Neuropathological Society on 11 January 1989, at the Institute of Neurology, London. AboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onEmailFacebookTwitterLinkedInRedditWechat References BALL M.J. (1976) Neurofibrillary tangles and the pathogenesis of dementia; a quantitative study. Neuropathology and Applied Neurobiology 2, 395–410. BALL M. J., GRIFFITH–BROOKS S., MACGREGOR J., NAGY B., OJALVO–ROSE E. & FEWSTER P. H. (1988) Neuropathological definition of Alzheimer's disease: Multivariate analyses in the morphometric distinction between Alzheimer dementia and normal aging. Alzheimer's Disease and Associated Disorders 2, 29–37. BARCIKOWSKA M., WISNIEWSKI H. M., BAN CHER C. & GRUNDE–IQBAL I. (1989) About the presence of paired helical filaments in dystrophic neurites participating in the plaque formation. Acta Neuropathologica 78, 225–231. BOLLER F., MITZUTANI T., ROESSMAN U. & GAMBETTI P. (1980) Parkinson disease, dementia and Alzheimer disease: clinicopathological correlations. Annals of Neurology 7, 329–335. BRAAK H. & BRAAK E. (1988) Neuropil threads occur in dendrites of tangle–bearing nerve cells. Neuropathology and Applied Neurobiology 14, 39–44. BRAAK H., BRAAK E., GRUNKLE–IQBAL I. & IQBAL K. (1986) Occurrence of neuropil threads in the senile human brain and in Alzheimer's disease: a third location of paired helical filaments outside of neurofibrillary tangles and neuritic plaques. Neuroscience Letters 65, 351–355. BRUN A. & ENGLUND E. (1981) The regional pattern of degeneration in Alzheimer's disease; neuronal loss and histopathological grading. Histopathology 5, 549–564. BYRNE E. J., LOWE J., GODWIN–AUSTEN R. B., ARIE T. & JONES R. (1987) Dementia and Parkinson's disease associated with diffuse cortical Lewy bodies. Lancet I, 501. CONSTANTINIDIS J. (1978) Is Alzheimer's disease a major form of senile dementia? Clinical, anatomical and genetic data. In Aging Alzheimer's Disease, Senile Dementia and Related Disorders, Eds. H. Katzman, R. D. Terry & K.L. Bick, pp. 15–25. Raven Press, New York . CURCIO C. A. & KEMPER T. (1984) Nucleus raphe dorsalis in dementia of the Alzheimer type. Neurofibrillary changes and neuronal packing density. Journal of Neuropathology and Experimental Neurology 43, 359–368. DUARA R., GRADY C., HAXBY J., SUNDARAM M., CUTLER R., HESTON L., MOORE A., SCHLAGETER N., LARSON S. & RAPOPORT S. I. (1986) Positron emission tomography in Alzheimer's disease. Neurology 36, 879–887. ESIRI M. M., PEARSON R.C.A. & POWELL T.P.S. (1986) The cortex of the primary auditory area in Alzheimer's disease. Brain Research 366, 385–388. FORNO L. S., BARBOUR P. J. & NORVILLE R. L. (1978) Presenile dementia with Lewy bodies and neurofibrillary tangles. Archives of Neurology 35, 818–822. GIBB W.R.G., ESIRI M. M. & LEES A. J. (1985) Clinical pathological features of diffuse cortical Lewy body disease (Lewy body dementia). Brain 110, 1131–1153. HAKIM A. M. & MATHIEWSON G. (1979) Dementia in Parkinson disease: a neuropathologic study. Neurology 29, 1209–1214. HAXBY J. V., GRADY C. L., DUARA R., SCHLAGETER N., BERG G. & RAPOPORT S. I. (1986) Neocortical metabolic abnormalities precede non–memory cognitive defects in early Alzheimer type dementia. Archives of Neurology 37, 625–629. HUBBARD B. M. & ANDERSON J. M. (1981) A quantitative study of cerebral atrophy in old age and senile dementia. Journal of the Neurological Sciences 50, 135–145. HUBBARD B. M. & ANDERSON J. M. (1985) Age–related variations in the neuron content of the cerebral cortex in senile dementia of Alzheimer type. Neuropathology and Applied Neurobiology 11, 369–382. IHARA Y. (1988) Massive somato–dendritic sprouting of cortical neurons in Alzheimer's disease. Brain Research 459, 138–144. IKEDA K., IKEDA S., YOSHIMURA T., KATO H. & NAMBA M. (1978) Idiopathic Parkinsonism with Lewy–type inclusions in cerebral cortex; a case report. Acta Neuropathologica (Berlin) 41, 165–168. ISHII T. (1966) Distribution of Alzheimer's neurofibrillary changes in the brain stem and hypothalamus of senile dementia. Acta Neuropathologica 6, 181–187. JACOBY R. J. & LEVY R. (1980) Computed tomography in the elderly. Senile dementia, diagnosis and functional impairment. British Journal of Psychiatry 36, 256–269. JELLINGER K. & GRISOLD W. (1982) Cerebral atrophy in Parkinson syndrome. Experimental Brain Research (suppl. 5). pp. 26–35. Springer–Verlag, Berlin . JOACHIM C. L., MORRIS J. H. & SELKOE D. J. (1989) Diffuse amyloid plaques occur commonly in the cerebellum in Alzheimer's disease. American Journal of Pathology (submitted for publication). JOHNSON K. A., HOLMAN L., MUELLER S. P., ROSEN J., ENGLISH R., NAGEL J. S. & GROWDON J. H. (1988) Single photon emission computed tomography in Alzheimer's disease. Abnormal iofetamine I123 uptake reflects dementia severity. Archives of Neurology 45, 492–396. KATO T., HIRANO A., KATAGIRI T., SASAKI H. & YAMADA S. (1988) Neurofibrillary tangle formation in the nucleus basalis of Meynert ipsilateral to a massive cerebral infarct. Annals of Neurology 23, 620–623. KATZMAN R., TERRY R. D., DETERESA R., BROWN T., DAVIES P., FULD P., RENBING X. & PECK A. (1988) Clinical, pathological and neurochemical changes in dementia: a subgroup with preserved mental status and numerous cortical plaques. Annals of Neurology 23, 138–144. KHACHATURIAN Z.S. (1985) Diagnosis of Alzheimer's disease. Archives of Neurology 42, 1097–1105. KOSAKA K. (1978) Lewy bodies in cerebral cortex. Report of three cases. Acta Neuropathologica (Berlin) 42, 127–134. MANN D.M.A., MARCYNIUK B., YATES P. O., NEARY D. & SNOWDEN J. S. (1988) The progression of the pathological changes of Alzheimer's disease in frontal and temporal neocortex examined both at biopsy and at autopsy. Neuropathology and Applied Neurobiology 14, 177–195. MANN D.M.A., YATES P. O. & MARCYNIUK B. (1985) Some morphometric observations on the cerebral cortex and hippocampus in presenile Alzheimer's disease, senile dementia of Alzheimer type and Down's syndrome in middle age. Journal of the Neurological Sciences 69, 139–159. NAJLERAHIM A. & BOWEN D. M. (1988) Regional weight loss of the cerebral cortex and some subcortical nuclei in senile dementia of the Alzheimer type. Acta Neuropathologica (Berlin) 75, 509–512. OKAZAKI H., LIPKIN L. E. & ARONSON S. M. (1961) Diffuse intracytoplasmic ganglionic inclusions (Lewy type) associated with progressive dementia and quadriparesis in flexion. Journal of Neuropathology and Experimental Neurology 20, 237–244. PEARSON R.C.A., ESIRI M. M., HIORNS R. W., WILCOCK G. K. & POWELL T.P.S. (1985) Anatomical correlates of the distribution of the pathological changes in the neocortex in Alzheimer's disease. Proceedings of the National Academy of Sciences USA 82, 4531–4534. PERRY E. K., CURTIS M., DICK D. J., CANDY J. M., ATACK J. R., BLOXHAM C. A., BLESSED G.. FAIRBURN A. F., TOMLINSON B. E. & PERRY R. H. (1985) Cholinergic correlates of cognitive impairment in Parkinson's disease: comparisons with Alzheimer's disease. Journal of Neurology Neurosurgery and Psychiatry 48, 413–421. PERRY R. H., IRVING D., BLESSED G., PERRY E. K. & FAIRBURN A. F. (1989) Clinically and neuropathologically distinct form of dementia in the elderly. Lancet I, 166. PROBST A., ANDERTON B. H., BRION J. P. & ULRICH J. (1989) Senile plaque neurites fail to demonstrate anti–paired helical filament and anti–mierotubule–assoeiated protein–tau immunoreactive proteins in the absence of neurofibrillary tangles in the neocortex. Acta Neuropathologica 77, 430–436. PROBST A., LANGIRI D., LAUTENSHLAGER C., ULRICH J., BRION J. P. & ANDERTON B. H. (1988) Progressive supranuclear palsy: extensive neuropil threads in addition to neurofibrillary tangles. Acta Neuropathologica (Berlin) 77, 61–68. ROBERTS G. W., ALLSOP D. & BRUTON C. (1989) The occult aftermath of boxing. Journal of Neurology, Neurosurgery and Psychiatry (accepted for publication). SIES H. (1988) A new parameter for sex education. Nature 322, 495. SMITH T. W., ANWER U., de GIROLAMI U. & DRACHMAN D. A. (1987) Vacuolar change in Alzheimer's disease. Archives of Neurology 44, 1225–1228. STRUBLE R. G., POWERS R. E., CASANOVA M. F., KITT C. A., BROWN E. C. & PRICE D. L. (1987) Neuropeptidendic systems in plaques of Alzheimer's disease. Journal of Neuropathology and Experimental Neurology 46, 567–584. TAN N., MASTAGLIA F. L., MASTERS C. L., BEYREUTHER K. & KAKULAS B. A. (1988) Amyloid (A4) protein deposition in brain in progessive supranuclear palsy (p.s.p.) Alzheimer's Disease and Associated Disorders 2, 264. TERRY R. D., DAVIES P., DETERESA R. & KATZMAN R. (1982) Are both plaques and tangles required to make it Alzheimer's disease Journal of Neuropathology and Experimental Neurology 41, 364. TERRY R. D. & HANSEN L. A. (1987) Neocortieal cell counts in normal human adult ageing. Annals of Neurology 21, 530–539. TERRY R. D., HANSEN L. A., DETERESA R., DAVIES P., TOBIAS H. & KATZMAN R. (1987) Senile dementia of the Alzheimer type without neocortical neurofibrillary tangles. Journal of Neuropathology and Experimental Neurology 46, 262–268. TERRY R. D., PECK A., DETERESA R., SCHECKER R. & HORONPIAN D. S. (1981) Some morphometric aspects of the brain in senile dementia of the Alzheimer type. Annals of Neurology 10, 184–192. TOMLINSON B.E. (1972) Morphological brain changes in non–demented old people. In Ageing of the Central Nervous System, Eds. H.M. Praag & A.F. Kalverboer, pp. 37–57. Do Ervon F. Bohn, New York . TOMLINSON B.E. (1979) The ageing brain. In Recent Advances in Neuropathology, Eds. W. T. Smith & J.B. Cavanagh, pp. 129–159. Churchill Livingstone, London . TOMLINSON B.E. (1980) The structural and quantitative aspects of the dementias. In Biochemistry of Dementia, Ed. P. J. Roberts, pp. 15–52. John Wiley & Sons, Chichester . TOMLINSON B. E., BLESSED R. & ROTH M. (1970) Observations on the brains of demented old people. Journal of the Neurological Sciences 11, 205–242. TOMLINSON B. E. & CORSELLIS J.A.N. (1984) Ageing and the dementias. In Greenfield's Neuropathology, Eds. J. H. Adams, J.A.N. Corsellis & L.W. Duchen, pp. 951–1025. Edward Arnold, London . TOMLINSON B. E. & HENDERSON G. (1976) Some quantitative cerebral findings in normal and demented old people. In Neurobiology of Ageing, Volume 3, Eds. R. D. Terry & S. Gershon, pp. 183–204. Raven Press, New York . TOMLINSON B. E., IRVING D. & BLESSED G. (1981) Cell loss in the locus coeruleus in senile dementia of Alzheimer type. Journal of the Neurological Sciences 49, 419–428. TOMLINSON B. E. & KITCHENER D. (1972) Granulo–vacuolar degeneration of hippocampal pyramidal cells. Journal of Pathology 106, 165–185. ULRICH J. (1985) Alzheimer changes in non–demented patients younger than sixty–five; possible early stages of Alzheimer's disease and senile dementia of Alzheimer type. Annals of Neurology 17, 273–277. WALKER L. C., KITT C. A., CORK L. C., STRUBLE R. G., DELLOVADE T. L. & PRICE D. L. (1988) Multiple transmitter systems contribute neurites to individual senile plaques. Journal of Neuropathology and Experimental. Neurology 47, 138–144. WILCOCK G. K. & ESIRI M. M. (1982) Plaques, tangles and dementia; a quantitative study. Journal of the Neurological Sciences 56, 343–356. WILCOCK G. K., ESIRI M. M., BOWEN D. M. & HUGHES A. O. (1988) The differential involvement of subcortical nuclei in senile dementia of Alzheimer type. Journal of Neurology Neurosurgery & Psychiatry 51, 842–849. XUEREB J. H., PERRY R. H., PERRY E. K., CANDY J. M., MARSHALL E. & BONHAM J. R. (1989) The thalamus in Parkinson's disease and Alzheimer's disease: morphologic and neurochemical changes. Journal of Neuropathology and Applied Neurobiology 15, 274. XUEREB J. H., TOMLINSON B. E., PERRY R.H. PERRY E. K., FAIRBAIRN A. F. & BLESSED G. (1990) Dementia in Parkinson's disease: pathological considerations. In Advances in Neurology, Eds. M.B. Streifler, E. Melamed, A.D. Korezyn & M.B.H. Youdin. Raven Press, New York (in press). YAGASHITA S., ITOH Y., AMANO N. & NAKANO T. (1980) Atypical senile dementia with widespread Lewy type inclusion in the cerebral cortex. Acta Neuropathologica (Berlin) 49, 187–191. YAMAMOTO T. & HIRANO A. (1985) Nucleus raphe dorsalis in Alzheimer's disease: neurofibrillary tangles and loss of large neurons. Annals of Neurology 17, 573–577. YOSHIMURA M. (1983) Cortical changes in the Parkinsonian brain: a contribution to the delineation of 'diffuse Lewy body disease. Journal of Neurology 229, 17–33. Citing Literature Volume15, Issue6December 1989Pages 491-512 ReferencesRelatedInformation