Hijacking the Chromatin Remodeling Machinery: Impact of SWI/SNF Perturbations in Cancer
2009; American Association for Cancer Research; Volume: 69; Issue: 21 Linguagem: Inglês
10.1158/0008-5472.can-09-2166
ISSN1538-7445
AutoresBernard E. Weissman, Karen E. Knudsen,
Tópico(s)Cancer Mechanisms and Therapy
ResumoAbstract There is increasing evidence that alterations in chromatin remodeling play a significant role in human disease. The SWI/SNF chromatin remodeling complex family mobilizes nucleosomes and functions as a master regulator of gene expression and chromatin dynamics whose functional specificity is driven by combinatorial assembly of a central ATPase and association with 10 to 12 unique subunits. Although the biochemical consequence of SWI/SNF in model systems has been extensively reviewed, the present article focuses on the evidence linking SWI/SNF perturbations to cancer initiation and tumor progression in human disease. [Cancer Res 2009;69(21):8223–30]
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