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Efficacy of tricyclic antidepressants in irritable bowel syndrome: A meta-analysis

2009; Baishideng Publishing Group; Volume: 15; Issue: 13 Linguagem: Inglês

10.3748/wjg.15.1548

2219-2840

Roja Rahimi, Shekoufeh Nikfar, Ali Rezaie, Mohammad Abdollahi,

Music Therapy and Health

We a i m e d t o e va l u a t e t h e e ff i c a c y o f t r i c yc l i c antidepressants (TCAs) as a therapeutic option for irritable bowel syndrome (IBS) through meta-analysis of randomized controlled trials.For the years 1966 until September 2008, PubMed, Scopus, Web of Science, and Cochrane Central Register of Controlled Trials were searched for double-blind, placebo-controlled trials investigating the efficacy of TCAs in the management of IBS.Seven randomized, placebo-controlled clinical trials met our criteria and were included in the metaanalysis.TCAs used in the treatment arm of these trials included amitriptyline, imipramine, desipramine, doxepin and trimipramine.The pooled relative risk for clinical improvement with TCA therapy was 1.93 (95% CI: 1.44 to 2.6, P < 0.0001).Effect size of TCAs versus placebo for mean change in abdominal pain score among the two studies was -44.15 (95% CI:-53.27 to -35.04, P < 0.0001).It is concluded that low dose TCAs exhibit clinically and statistically significant control of IBS symptoms.