Direct Chiral Liquid Chromatographic Separation of Tocainide Enantiomers on a Crownpak (Cr) Column and its Application to Pharmaceutical Formulations and Biological Fluids
1991; Marcel Dekker; Volume: 14; Issue: 19 Linguagem: Inglês
10.1080/01483919108049404
ISSN2331-0413
AutoresHassan Y. Aboul‐Enein, Sherifa M. Abu‐Bakr, M. Rafiqul Islam, Robert Rothchild,
Tópico(s)Asymmetric Synthesis and Catalysis
ResumoAbstract Direct chiral liquid chromatographic resolution of racemic tocainide was accomplished without any derivatization using a crownpak CR(+) column as a chiral stationary phase. The stereochemical resolution (R) with symmetrical peaks was 0.97 and a separation factor (α) of 1.44 were obtained. Optimization of separation was achieved using different concentrations of perchloric acid.
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