Studies towards the synthesis of guanidine alkaloids; synthesis of a tricyclic guanidine from succinimide
1996; Elsevier BV; Volume: 37; Issue: 6 Linguagem: Inglês
10.1016/0040-4039(95)02258-9
ISSN1873-3581
AutoresSaskia Louwrier, Martin Ostendorf, Antonin Tuynman, Henk Hiemstra,
Tópico(s)Chemical Synthesis and Analysis
ResumoThe synthesis of a tricyclic guanidine as a model compound for ptilomycalin A and related guanidine alkaloids is described. The synthesis starts from succinimide and features an N-acyliminium ion coupling, an Eschenmoser sulfide-contraction and an N-guanylation as the key steps.
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