Genetic and sex‐linked factors influencing hbs antigen clearance 1. nonimmune clearance in inbred strains of mice
1982; Wiley; Volume: 9; Issue: 2 Linguagem: Inglês
10.1002/jmv.1890090206
ISSN1096-9071
AutoresAntonio Craxı̀, Luis F. Montaño, Alison H. Goodall, Howard C. Thomas,
Tópico(s)Protein purification and stability
ResumoAbstract Differences in the clearance values of polyvinylpyrrolidonc (K PVP ) and HBs antigen (K HBs ) were seen in several strains of inbred mice. In addition, in all strains studied K HBs was greater in females than in males, while K PVP was not significantly different in the two sexes. In the strain with the lowest K HBs values, the incidence of HBs antibody formation was lower than in the other strains. These data indicate that genetic and sex‐linked factors influence nonimmune clearance of HBs antigen in mice. If similar factors exist in man they may explain some of the variation in clinical manifestation of HBV infection.
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