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Cilia at the Node of Mouse Embryos Sense Fluid Flow for Left-Right Determination via Pkd2

2012; American Association for the Advancement of Science; Volume: 338; Issue: 6104 Linguagem: Inglês

10.1126/science.1222538

1095-9203

Satoko Yoshiba, Hidetaka Shiratori, Ivana Y. Kuo, Aiko Kawasumi, Kyosuke Shinohara, Shigenori Nonaka, Yasuko Asai, Genta Sasaki, José António Belo, Hiroshi Sasaki, Junichi Nakai, Bernd Dworniczak, Barbara E. Ehrlich, Petra Pennekamp, Hiroshi Hamada,

Protist diversity and phylogeny

Distinguishing Right from Left In most vertebrates during embryonic development, rotational movement of the cilia within a structure in the embryo, known as the node, generates unidirectional flow required for future left-right asymmetry of the internal organs. The flow may transport a determinant molecule or provide mechanical force. However, it is not clear how the flow is sensed. Yoshiba et al. (p. 226 , published online 13 September; see the Perspective by Norris and Grimes ) show that nodal flow in mouse embryos is sensed by the cilia of perinodal cells located at the edge of the node, in a manner dependent on Pkd2, a Ca 2+ -permeable cation channel that has been implicated in polycystic kidney disease in humans.