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Reversible dilated cardiomyopathy associated with amphotericin B therapy
2014; Wiley; Volume: 40; Issue: 3 Linguagem: Inglês
10.1111/jcpt.12237
ISSN1365-2710
AutoresJanaína Soares, Maria Carmo Pereira Nunes, Anderson Ferreira Leite, Eduardo Belisário Falqueto, B. E. R. A. Lacerda, Teresa Cristina Abreu Ferrari,
Tópico(s)Fungal Infections and Studies
ResumoJournal of Clinical Pharmacy and TherapeuticsVolume 40, Issue 3 p. 333-335 Case Report Reversible dilated cardiomyopathy associated with amphotericin B therapy J. R. Soares MD, J. R. Soares MD Hospital das Clinicas of the Universidade Federal de Minas Gerais, Belo Horizonte, MG, BrazilSearch for more papers by this authorM. C. P. Nunes MD PhD, Corresponding Author M. C. P. Nunes MD PhD Hospital das Clinicas of the Universidade Federal de Minas Gerais, Belo Horizonte, MG, Brazil Department of Internal Medicine, School of Medicine of the Universidade Federal de Minas Gerais, Belo Horizonte, MG, BrazilCorrespondence: Prof Maria Carmo P. Nunes, Department of Internal Medicine, School of Medicine of the Federal University of Minas Gerais; Av. Professor Alfredo Balena 190, 30130-100, Belo Horizonte, MG, Brazil. Tel.: +55 31 34099746, fax: +55 31 34099437; e-mail: [email protected]Search for more papers by this authorA. F. Leite MD, A. F. Leite MD Hospital das Clinicas of the Universidade Federal de Minas Gerais, Belo Horizonte, MG, BrazilSearch for more papers by this authorE. B. Falqueto MD, E. B. Falqueto MD Hospital das Clinicas of the Universidade Federal de Minas Gerais, Belo Horizonte, MG, BrazilSearch for more papers by this authorB. E. R. A. Lacerda MD, B. E. R. A. Lacerda MD Hospital das Clinicas of the Universidade Federal de Minas Gerais, Belo Horizonte, MG, BrazilSearch for more papers by this authorT. C. A. Ferrari MD PhD, T. C. A. Ferrari MD PhD Hospital das Clinicas of the Universidade Federal de Minas Gerais, Belo Horizonte, MG, Brazil Department of Internal Medicine, School of Medicine of the Universidade Federal de Minas Gerais, Belo Horizonte, MG, BrazilSearch for more papers by this author J. R. Soares MD, J. R. Soares MD Hospital das Clinicas of the Universidade Federal de Minas Gerais, Belo Horizonte, MG, BrazilSearch for more papers by this authorM. C. P. Nunes MD PhD, Corresponding Author M. C. P. Nunes MD PhD Hospital das Clinicas of the Universidade Federal de Minas Gerais, Belo Horizonte, MG, Brazil Department of Internal Medicine, School of Medicine of the Universidade Federal de Minas Gerais, Belo Horizonte, MG, BrazilCorrespondence: Prof Maria Carmo P. Nunes, Department of Internal Medicine, School of Medicine of the Federal University of Minas Gerais; Av. Professor Alfredo Balena 190, 30130-100, Belo Horizonte, MG, Brazil. Tel.: +55 31 34099746, fax: +55 31 34099437; e-mail: [email protected]Search for more papers by this authorA. F. Leite MD, A. F. Leite MD Hospital das Clinicas of the Universidade Federal de Minas Gerais, Belo Horizonte, MG, BrazilSearch for more papers by this authorE. B. Falqueto MD, E. B. Falqueto MD Hospital das Clinicas of the Universidade Federal de Minas Gerais, Belo Horizonte, MG, BrazilSearch for more papers by this authorB. E. R. A. Lacerda MD, B. E. R. A. Lacerda MD Hospital das Clinicas of the Universidade Federal de Minas Gerais, Belo Horizonte, MG, BrazilSearch for more papers by this authorT. C. A. Ferrari MD PhD, T. C. A. Ferrari MD PhD Hospital das Clinicas of the Universidade Federal de Minas Gerais, Belo Horizonte, MG, Brazil Department of Internal Medicine, School of Medicine of the Universidade Federal de Minas Gerais, Belo Horizonte, MG, BrazilSearch for more papers by this author First published: 09 December 2014 https://doi.org/10.1111/jcpt.12237Citations: 12Read the full textAboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Summary What is known and objective Amphotericin B (AmB) is commonly used to treat a broad spectrum of fungal infections and leishmaniasis. Its use is limited by numerous adverse effects. Reversible dilated cardiomyopathy associated with AmB is a rare disorder with only four previously reported cases, and all of them referring to patients who presented with a predisposing factor for heart failure. Case summary A previously healthy 45-year-old man with visceral leishmaniasis treated with AmB developed acute dilated cardiomyopathy. Other causes of heart failure as well-known predisposing factors for this condition were ruled out. As with previously reported cases, the cardiac function of our patient returned to normal shortly after. What is new and conclusion We describe the first case of dilated cardiomyopathy associated with the administration of AmB in a patient without any known predisposing factor for developing cardiac dysfunction. Available evidence suggests that AmB may induce cardiotoxicity. Further investigations are needed to clarify this issue. Citing Literature Volume40, Issue3June 2015Pages 333-335 RelatedInformation
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