Primary Cutaneous CD30(Ki-1)-Positive Lymphoma of Non-T, Non-B Origin
1995; Karger Publishers; Volume: 190; Issue: 3 Linguagem: Inglês
10.1159/000246696
ISSN1421-9832
AutoresChihiro Akiyama, Naotaka Shibagaki, Nami Yasaka, Naoto OHTAKE, Y. Kuhota, Osamu Takayama, Ryohei Katoh, Shinji Shimada, Masutaka Furue, K. Tamaki,
Tópico(s)Fungal Infections and Studies
ResumoA 71-year-old Japanese woman had two dome-shaped tumors on her right buttock with several surrounding papules. Histological examination revealed that large anaplastic cells and atypical lymphoid cells densely infiltrated the entire dermis. On immunohistochemical examination, Ki-1, HLA-DR, CD25 (IL-2 receptor alpha), CD122 (IL-2 receptor beta), CD4, CD11c and CD68 were all positive in the tumor cells, whereas CD1a, CD3, CD5, CD8 and CD19 were negative. Neither rearrangement of the T-cell receptor beta, T-cell receptor gamma nor the immunoglobulin heavy-chain was seen. Ultrastructurally, most of the tumor cells contained thick bundles of intermediate filaments in the perinuclear cytoplasm. Thus, this patient was diagnosed as having Ki-1-positive lymphoma of non-T, non-B origin. No recurrence or metastasis of the tumor has been observed in the last 2 years, although surgical resection was required 3 times before control was achieved.
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