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Antidepressant Use in Pregnancy and the Risk of Cardiac Defects

2014; Massachusetts Medical Society; Volume: 370; Issue: 25 Linguagem: Inglês

10.1056/nejmoa1312828

1533-4406

Krista F. Huybrechts, Kristin Palmsten, Jerry Avorn, Lee S. Cohen, Lewis B. Holmes, Jessica M. Franklin, Helen Mogun, Raisa Levin, Mary K. Kowal, Soko Setoguchi, Sonia Hernández–Dı́az,

Child and Adolescent Psychosocial and Emotional Development

Whether the use of selective serotonin-reuptake inhibitors (SSRIs) and other antidepressants during pregnancy is associated with an increased risk of congenital cardiac defects is uncertain. In particular, there are concerns about a possible association between paroxetine use and right ventricular outflow tract obstruction and between sertraline use and ventricular septal defects.