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Systemic and cardiac hemodynamic interactions between clonidine and minoxidil

1981; Wiley; Volume: 30; Issue: 2 Linguagem: Inglês

10.1038/clpt.1981.142

1532-6535

Manuel Velasco, Pedro Andrews‐Figueroa, Ana K Ramírez, Julio Morillo, Adalberto Urbina‐Quintana, Ricardo Alienares, O Hernández-Pieretti,

Anesthesia and Sedative Agents

We examined the hemodynamic interaction between clonidine, a centrally acting antiadrenergic drug, and minoxidil, a potent antihypertensive vasodilator in 10 inpatients with refractory or accelerated hypertension or both. Clonidine in oral doses of 150 to 900 μg/day decreased average mean blood pressure 18.6 mm Hg (p < 0.01), average heart rate 16.4 bpm (p < 0.01), limb blood flow 1.63 ml/100 gm · min (p < 0.05), and plasma renin activity 1.13 ng/ml · hr (p < 0.025). It also increased the pre‐ejection period index 12.4 msec (p < 0.001), but did not alter the cardiac or total peripheral resistance indices. The addition of minoxidil in oral doses of 5 to 22.5 mg/day further decreased average mean blood pressure 24.2 mm Hg (p < 0.01), preejection period index 20.6 msec (p < 0.01), limb vascular resistance 13.2 mm Hg/min · 100 gm/ml (p < 0.05), and total peripheral resistance 13.3 mm Hg/min · m 2 /l (p < 0.01), pre‐ejection period index 20.6 msec (p < 0.01), limb vascular resistance 13.2 mm Hg/min · 100 gm/ml (p < 0.05), and total peripheral resistance 13.3 mm Hg/min · m 2 /l concluded that clonidine can be used as an alternative to β‐adrenergic blockers to counteract the increased sympathetic nervous activity minoxidil induces. Clinical Pharmacology and Therapeutics (1981) 30, 158–163; doi: 10.1038/clpt.1981.142