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BIBTEX RIS

Association between DNA strand breakage and oxidative, inflammatory and endothelial biomarkers in type 2 diabetes

2012; Elsevier BV; Volume: 732; Issue: 1-2 Linguagem: Inglês

10.1016/j.mrfmmm.2012.01.004

ISSN

1873-135X

Autores

Etiane Tatsch, Guilherme Vargas Bochi, Silvia Piva, José Antônio Mainardi de Carvalho, Helena Kober, Vanessa Dorneles Torbitz, Thiago Duarte, Cristiane Signor, Adriane C. Coelho, Marta Maria Medeiros Frescura Duarte, Greice F.F.S. Montagner, Ivana Beatrice Mânica da Cruz, Rafael Noal Moresco,

Tópico(s)

Glutathione Transferases and Polymorphisms

Resumo

Evidence has been presented recently that type 2 diabetes patients have an increased level of DNA damage. This DNA damage could be associated with oxidative, inflammatory, and endothelial biomarkers and could represent a possible indication of injury in the endothelium and induction of inflammation in type 2 diabetes. To confirm this possible association, DNA strand breakage was evaluated by use of the comet assay and its association with oxidative, inflammatory, and endothelial biomarkers in type 2 diabetes patients. A case-control study (30 healthy controls and 32 subjects with type 2 diabetes) was performed to evaluate the association between DNA damage and NOx (nitrate/nitrite), interleukin-6 (IL-6), urinary albumin, fasting glucose, and glycated hemoglobin (HbA(1c)) levels. Type 2 diabetes patients presented higher DNA damage than control subjects, higher levels of IL-6 and urinary albumin, and lower NOx. Significant correlations between DNA damage and NOx (r=-0.303, p=0.016), IL-6 (r=0.845, p<0.001), urinary albumin (r=0.496, p<0.001), fasting glucose (r=0.449, p<0.001), and HbA(1c) (r=0.575, p<0.001) were reported. Our findings showed an increase of DNA damage in type 2 diabetes especially in those patients with poor glycemic control and associations among NOx, IL-6 and urinary albumin levels with DNA damage.

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