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Effect of slaframine on exocrine gland function

1970; Elsevier BV; Volume: 19; Issue: 2 Linguagem: Inglês

10.1016/0006-2952(70)90198-x

1873-2968

Steven D. Aust,

Diet, Metabolism, and Disease

The administration of slaframine to animals results in a sustained increase in secretory activity by the exocrine glands. A quantitative study of pancreatic secretions was undertaken to better define the consequences of the stimulation of exocrine glands by slaframine. After a brief delay, presumably due to the bioactivation of slaframine, there is a substantial and prolonged increase in the rate of secretion. The increased activity of the digestive enzymes in the pancreatic fluid is not accompanied by an equal increase in the total protein content, suggesting a specific increase in the synthesis of the digestive enzymes. The increased protein synthesis was confirmed by measurement of the incorporation of labeled amino acids into pancreatic proteins. The increased rate of secretion is accompanied by a decreased concentration of mucoproteins, but only a very slight decrease in viscosity was observed. These results indicate that slaframine results in a prolonged stimulation of pancreatic secretory activity and is selective in stimulating the synthesis of digestive enzymes.