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Effects of flaxseed(Linum usitatissimum) chutney on gamma-glutamyl transpeptidase and micronuclei profile in azoxymethane treated rats

2007; Springer Nature; Volume: 22; Issue: 2 Linguagem: Inglês

10.1007/bf02913330

0970-1915

K. A. Faseehuddin Shakir, Basavaraj Madhusudhan,

Nutritional Studies and Diet

Antioxidant property of flaxseed chutney was evident by decreasing lipid peroxidation (TBARS) and predictor enzyme γ-glutamyl transpeptidase profile and micronuclei formation in azoxymethane treated rats. After 10 weeks, rats fed with either fiber-free basal diet or Antioxidant diet exhibited over sevenfold increase in γ-glutamyl transpeptidase activity and nearly fourfold increase in micronuclei load in comparison to controls (p<0.001). A significant reduction in both γ-glutamyl transpeptidase level (52%) and micronuclei formation (47%) was observed in fiber-free basal diet/Antioxidant diet/flaxseed chutney diet fed rats. Relative to rats fed fiber-free basal diet, the profile of γ-glutamyl transpeptidase and micronuclei load was not significantly altered.