Produção Nacional
Revisado por pares
Recent Developments in the Chemistry of Deoxyribonucleic Acid (DNA) Intercalators: Principles, Design, Synthesis, Applications and Trends
2009; Multidisciplinary Digital Publishing Institute; Volume: 14; Issue: 5 Linguagem: Inglês
10.3390/molecules14051725
ISSN1433-1373
AutoresBrenno A. D. Neto, Alexandre A.M. Lapis,
Tópico(s)Click Chemistry and Applications
ResumoIn the present overview, we describe the bases of intercalation of small molecules (cationic and polar neutral compounds) in DNA. We briefly describe the importance of DNA structure and principles of intercalation. Selected syntheses, possibilities and applications are shown to exemplify the importance, drawbacks and challenges in this pertinent, new, and exciting research area. Additionally, some clinical applications (molecular processes, cancer therapy and others) and trends are described.
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