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Collagenous Gastritis

2001; Lippincott Williams & Wilkins; Volume: 25; Issue: 9 Linguagem: Inglês

10.1097/00000478-200109000-00008

1532-0979

Christine Lagorce-Pagès, Bettina Fabiani, Raymonde Bouvier, Jean‐Yves Scoazec, Luc Durand, Jean–François Fléjou,

Potassium and Related Disorders

Collagenous gastritis is an exceptional entity with eight cases documented to date characterized by the presence of a thick subepithelial collagen band associated with an inflammatory infiltrate of the gastric mucosa. The aim of our study was to describe the clinical and histologic characteristics of six new cases of collagenous gastritis. All cases showed a subepithelial collagen band that averaged 30 μm but often measured up to 120 μm. This finding was almost always accompanied by mixed chronic inflammation in the lamina propria and by surface epithelial damage of varying severity. Our study seems to delineate two subsets in patients with collagenous gastritis: 1) collagenous gastritis occurring in children and young adults presenting with severe anemia, a nodular pattern on endoscopy, and a disease limited to the gastric mucosa without evidence of colonic involvement, and 2) collagenous gastritis associated with collagenous colitis occurring in adult patients presenting with chronic watery diarrhea. These findings highlight the fact that subepithelial collagen deposition may be a generalized disease affecting the entire gastrointestinal tract.