Autoimmune progesterone dermatitis: absence of contact sensitivity to glucocorticoids, oestrogen and 17-α-OH-progesterone
1994; Wiley; Volume: 31; Issue: 2 Linguagem: Inglês
10.1111/j.1600-0536.1994.tb01928.x
ISSN1600-0536
AutoresCatherine J.M. Stephens, John Mcfadden, Martin M. Black, R. J. G. Rycroft,
Tópico(s)Contact Dermatitis and Allergies
ResumoAutoimmune progesterone dermatitis is a rare condition, characterized by recurrent premenstrual exacerbations of a dermatosis, in which sensitivity to progesterone can be demonstrated. The sensitizing mechanism is unknown. The aim of this study was to test the hypothesis that cross‐sensitivity between steroid groups could induce allergy to endogenous progesterone in these patients. 5 patients with autoimmune progesterone dermatitis and 1 with oestrogen‐sensitive dermatitis have been patch tested with a corticosteroid series, conjugated oestrogen 1% in petrolatum (pet.), and 17‐α‐OH‐progesterone 2% pet. There were no immediate or delayed reactions at 2 and 4 days to any steroid group. We have therefore been unable to demonstrate steroid cross‐sensitivity, or a use for 17‐α‐OH‐progesterone in the investigation of oestrogen ‐ and progesterone‐sensitive dermatoses.
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