Selective photothermolysis of lipid-rich tissues: A free electron laser study
2006; Wiley; Volume: 38; Issue: 10 Linguagem: Inglês
10.1002/lsm.20393
ISSN1096-9101
AutoresR. Rox Anderson, William A. Farinelli, Hans‐Joachim Laubach, Dieter Manstein, Anna N. Yaroslavsky, Joseph Gubeli, K. Jordan, George R. Neil, Michelle D. Shinn, W K Chandler, Gwyn Williams, Steven V. Benson, D. Douglas, H.F. Dylla,
Tópico(s)Skin Protection and Aging
ResumoLasers in Surgery and MedicineVolume 38, Issue 10 p. 913-919 Preclinical Reports Selective photothermolysis of lipid-rich tissues: A free electron laser study† R. Rox Anderson MD, Corresponding Author R. Rox Anderson MD [email protected] Wellman Center for Photomedicine, Harvard Medical School, Boston, MassachusettsDirector, Wellman Center for Photomedicine, BHX-630, Massachusetts General Hospital, Boston, MA 02114.Search for more papers by this authorWilliam Farinelli BA, William Farinelli BA Wellman Center for Photomedicine, Harvard Medical School, Boston, MassachusettsSearch for more papers by this authorHans Laubach MD, Hans Laubach MD Wellman Center for Photomedicine, Harvard Medical School, Boston, MassachusettsSearch for more papers by this authorDieter Manstein MD, PhD, Dieter Manstein MD, PhD Wellman Center for Photomedicine, Harvard Medical School, Boston, MassachusettsSearch for more papers by this authorAnna N. Yaroslavsky PhD, Anna N. Yaroslavsky PhD Wellman Center for Photomedicine, Harvard Medical School, Boston, MassachusettsSearch for more papers by this authorJoseph Gubeli III MS, Joseph Gubeli III MS Thomas Jefferson National Accelerator Facility, Newport News, VirginiaSearch for more papers by this authorKevin Jordan PE, Kevin Jordan PE Thomas Jefferson National Accelerator Facility, Newport News, VirginiaSearch for more papers by this authorGeorge R. Neil PhD, George R. Neil PhD Thomas Jefferson National Accelerator Facility, Newport News, VirginiaSearch for more papers by this authorMichelle Shinn PhD, Michelle Shinn PhD Thomas Jefferson National Accelerator Facility, Newport News, VirginiaSearch for more papers by this authorWalter Chandler MD, Walter Chandler MD Thomas Jefferson National Accelerator Facility, Newport News, VirginiaSearch for more papers by this authorGwyn P. Williams PhD, Gwyn P. Williams PhD Thomas Jefferson National Accelerator Facility, Newport News, VirginiaSearch for more papers by this authorSteven V. Benson PhD, Steven V. Benson PhD Thomas Jefferson National Accelerator Facility, Newport News, VirginiaSearch for more papers by this authorDavid R. Douglas PhD, David R. Douglas PhD Thomas Jefferson National Accelerator Facility, Newport News, VirginiaSearch for more papers by this authorH.F. Dylla PhD, H.F. Dylla PhD Thomas Jefferson National Accelerator Facility, Newport News, VirginiaSearch for more papers by this author R. Rox Anderson MD, Corresponding Author R. Rox Anderson MD [email protected] Wellman Center for Photomedicine, Harvard Medical School, Boston, MassachusettsDirector, Wellman Center for Photomedicine, BHX-630, Massachusetts General Hospital, Boston, MA 02114.Search for more papers by this authorWilliam Farinelli BA, William Farinelli BA Wellman Center for Photomedicine, Harvard Medical School, Boston, MassachusettsSearch for more papers by this authorHans Laubach MD, Hans Laubach MD Wellman Center for Photomedicine, Harvard Medical School, Boston, MassachusettsSearch for more papers by this authorDieter Manstein MD, PhD, Dieter Manstein MD, PhD Wellman Center for Photomedicine, Harvard Medical School, Boston, MassachusettsSearch for more papers by this authorAnna N. Yaroslavsky PhD, Anna N. Yaroslavsky PhD Wellman Center for Photomedicine, Harvard Medical School, Boston, MassachusettsSearch for more papers by this authorJoseph Gubeli III MS, Joseph Gubeli III MS Thomas Jefferson National Accelerator Facility, Newport News, VirginiaSearch for more papers by this authorKevin Jordan PE, Kevin Jordan PE Thomas Jefferson National Accelerator Facility, Newport News, VirginiaSearch for more papers by this authorGeorge R. Neil PhD, George R. Neil PhD Thomas Jefferson National Accelerator Facility, Newport News, VirginiaSearch for more papers by this authorMichelle Shinn PhD, Michelle Shinn PhD Thomas Jefferson National Accelerator Facility, Newport News, VirginiaSearch for more papers by this authorWalter Chandler MD, Walter Chandler MD Thomas Jefferson National Accelerator Facility, Newport News, VirginiaSearch for more papers by this authorGwyn P. Williams PhD, Gwyn P. Williams PhD Thomas Jefferson National Accelerator Facility, Newport News, VirginiaSearch for more papers by this authorSteven V. Benson PhD, Steven V. Benson PhD Thomas Jefferson National Accelerator Facility, Newport News, VirginiaSearch for more papers by this authorDavid R. Douglas PhD, David R. Douglas PhD Thomas Jefferson National Accelerator Facility, Newport News, VirginiaSearch for more papers by this authorH.F. Dylla PhD, H.F. Dylla PhD Thomas Jefferson National Accelerator Facility, Newport News, VirginiaSearch for more papers by this author First published: 12 December 2006 https://doi.org/10.1002/lsm.20393Citations: 174 † The authors certify that they have no affiliation with or financial involvement in any anganization or entity with a direct financial interest in the subject matter or material discussed in the manuscript. AboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Abstract Background and Objectives In theory, infrared vibrational bands could be used for selective photothermolysis of lipid-rich tissues such as fat, sebaceous glands, or atherosclerotic plaques. Study Design/Materials and Methods Absorption spectra of human fat were measured, identifying promising bands near 1,210 and 1,720 nm. Photothermal excitation of porcine fat and dermis were measured with a 3.5–5 µm thermal camera during exposure to the free electron laser (FEL) at Jefferson National Laboratory. Thermal damage to full-thickness samples exposed at ∼1,210 nm through a cold contact window, was assessed by nitrobluetetrazolium chloride staining in situ and by light microscopy. Results Photothermal excitation of fat was twice that of dermis, at lipid absorption bands (1,210, 1,720 nm). At 1,210 nm, a subcutaneous fat layer several mm thick was damaged by FEL exposure, without apparent injury to overlying skin. Conclusion Selective photothermal targeting of fatty tissues is feasible using infrared lipid absorption bands. Potential clinical applications are suggested by this FEL study. Lasers Surg. Med. 38:913–919, 2006. © 2006 Wiley-Liss, Inc. REFERENCES 1 Parrish JA, Anderson RR. Selective photothermolysis: Precise microsurgery by selective absorption of pulsed radiation. Science 1983; 220: 524– 527. 2 Altshuler GB, Anderson RR, Manstein D, Zenzie HH, Smirnov MZ. Extended theory of selective photothermolysis. 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