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Regulation of T-cell Responses and Disease by Tec Kinase Itk

2012; Taylor & Francis; Volume: 31; Issue: 2 Linguagem: Inglês

10.3109/08830185.2012.668981

1563-5244

Avery August, Melanie J. Ragin,

Chronic Lymphocytic Leukemia Research

Itk is a member of the Tec family tyrosine kinases involved in T-cell receptor signaling. The authors review the background and most recent findings of the role of Itk T-cell activation and development of αβ T cells. They also discuss the role of Itk in development of nonconventional T cells, including CD8+ innate memory phenotype T cells, different γδ T-cell populations, and invariant NKT cells. They close by reviewing the regulation of T helper differentiation and cytokine secretion, the immune response to infectious disease, and diseases such as allergic asthma and atopic dermatitis by Itk.