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Antifungal and antiviral activities of benanomicins and their analogues.

1991; Springer Nature; Volume: 44; Issue: 11 Linguagem: Inglês

10.7164/antibiotics.44.1228

1881-1469

Shinichi Kondo, Shuichi Gomi, Daishiro Ikeda, MASA HAMADA, TOMIO TAKEUCHI, Hideaki Iwai, Junichi Seki, Hiroo Hoshino,

Synthesis and Biological Evaluation

In vitro activities of benanomicins and their analogues against human immunodeficiency virus and fungi including Candida, Cryptococcus and Aspergillus, were examined. The free carboxyl group and at least one sugar moiety in the benanomicins were essential for their activities. Benanomicin A was most active and had low toxicity, and was selected as the best candidate for chemotherapy.