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Iridoid Glycosides of Leonurus persicus

1999; American Chemical Society; Volume: 62; Issue: 6 Linguagem: Inglês

10.1021/np980376e

1520-6025

Deniz Taşdemir, Léonardo Scapozza, Oliver Zerbe, Anthony Linden, İhsan Çalış, Otto Sticher,

Essential Oils and Antimicrobial Activity

Two new iridoid glucosides, 6-O-acetylajugol (1) and 7,8-epoxy-8-epi-loganic acid (2), together with five known iridoid glucosides, galiridoside (3), ajugoside (4), 10-deoxygeniposidic acid (5), 7-deoxy-8-epi-loganic acid (6), and 8-O-acetylharpagide (7), have been isolated from the aerial parts of Leonurus persicus. Leucosceptoside A (8), eugenyl β-rutinoside (9), and kaempferol 3-O-glucoside (10) were also isolated. The structures of 1 and 2 were elucidated by extensive 1D- and 2D-NMR spectroscopy and molecular modeling. The structure of 3 was confirmed by single-crystal X-ray diffraction. Antimicrobial activity of compounds (1−10) was also evaluated against a panel of Gram-positive and Gram-negative bacteria and two strains of fungi.