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Transmission of Integrase Strand-Transfer Inhibitor Multidrug-Resistant HIV-1: Case Report and Response to Raltegravir-Containing Antiretroviral Therapy

2011; SAGE Publishing; Volume: 16; Issue: 2 Linguagem: Inglês

10.3851/imp1748

2040-2058

Benjamin Young, Signe Fransen, Kenneth S. Greenberg, Amy Thomas, S. Martens, Marty St. Clair, Christos J. Petropoulos, Belinda Ha,

Biochemical and Molecular Research

We report the case of an integrase strand-transfer inhibitor (INI)-resistant and four-drug-class-resistant HIV-1 variant infecting an antiretroviral therapy-naive man. The virus harboured INI drug resistance substitutions (Q148H and G140S) along with multiple reverse transcriptase and protease inhibitor resistance mutations. This case illustrates an emerging need to consider the possibility of acquired INI resistance among newly diagnosed treatment-naive individuals harbouring multidrug-resistant HIV-1.