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Carbenicillin: a new semisynthetic penicillin active against Pseudomonas pyocyanea.

1967; BMJ; Volume: 3; Issue: 5557 Linguagem: Inglês

10.1136/bmj.3.5557.75

0959-8138

Elisa Knudsen, G. N. Rolinson, R. Sutherland,

Mycobacterium research and diagnosis

Carbenicillin (disodium a-carboxybenzylpenicillin; BRL 2064) is a new semisynthetic penicillin with a wide spectrum of activity against Gram-positive and Gram-negative bacteria.In particular, carbenicillin shows a certain level of activity against Pseudomonas pyocyanea (Pseudomonas aeruginosa), and the compound is also active against many strains of Proteus vulgaris, Proteus rettgeri, and Proteus morganii, which are typically resistant to ampicillin.The structure of carbenicillin is as follows:The compound, which should be stored in the refrigerator, is readily soluble in water, giving a clear neutral solution, which shows no significant loss of activity after 24 hours at room temperature and is stable in the refrigerator for at least seven days.In acid solution carbenicillin is relatively unstable, the half-life at pH 2 being approximately two hours at room temperature and approximately 30 minutes at 370 C. Sarcina lutea Clostridium tetani ,, welchii Minimum Inhibitory Concentration (isg./ml.)*5-0 250 12-5 5-0 5-0 50 2-5 5-0 2-5 5-0 0-5 0-5 50 0-25 25 0-5 1-25 0-5 0-25 0-25 * Serial dilution in agar; inoculum, one drop of an overnight culture.t Penicillinase-producing strain.Carbenicillin is active against Escherichia coli, Salmondla species, Shigella species, Proteus mirabilis, and Haemophilus influenzae, and in this respect the spectrum of activity is similar to that of ampicillin, although carbenicillin is in general rather less active than ampicillin.Most strains of Klebsiella aero- genes are resistant to carbenicillin and the level of activity against enterococci (Streptococcus faecalis) is relatively low.