Portal de Periódicos da CAPES

Screening fungi for the production of an inhibitor of HMG CoA reductase: Production of mevinolin by the fungi of the genus Pleurotus

1993; Oxford University Press; Volume: 111; Issue: 2-3 Linguagem: Inglês

10.1111/j.1574-6968.1993.tb06386.x

1574-6968

Nina Gunde‐Cimerman, JoÅ ⁄ ica Friedrich, Aleksa Cimerman, Neda Benički,

Plant biochemistry and biosynthesis

We have tested 380 strains of our Fungal Culture Collection (MZKIBK), for the activity of the inhibitor of HMG CoA reductase, mevinolin. All fungal strains were cultivated in a two-step submerged fermentation on selected substrates. For the first screening, samples of broth extracts were tested by TLC and positive results were further evaluated by HPLC analysis. In addition to already known microbiol producers of HMG CoA reductase inhibitors and some newly identified strains having moderate activity, we found that fungi of the basidiomycetous genus Pleurotus, especially species P. ostreatus, P. saca and P. sapidus, are an as yet unknown but promising source of the hypocholesterolaemic agent.