An Unprecedented Approach to 4,5-Disubstituted Pyrimidine Derivatives by a ZnCl 2 -Catalyzed Three-Component Coupling Reaction
2009; American Chemical Society; Volume: 11; Issue: 10 Linguagem: Inglês
10.1021/ol900382j
ISSN1523-7060
AutoresToshiaki Sasada, Fuminori Kobayashi, Norio Sakai, Takeo Konakahara,
Tópico(s)Catalytic C–H Functionalization Methods
ResumoWe have developed a ZnCl2-catalyzed three-component coupling reaction involving a variety of functionalized enamines, triethyl orthoformate, and ammonium acetate, which leads to the production of 4,5-disubstituted pyrimidine derivatives in a single step. The procedure can be successfully applied to the efficient synthesis of mono- and disubstituted pyrimidine derivatives, using methyl ketone derivatives instead of enamines.
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