Portal de Periódicos da CAPES

Hyponatremia increases mortality in pediatric patients listed for liver transplantation

2009; Wiley; Volume: 14; Issue: 1 Linguagem: Inglês

10.1111/j.1399-3046.2009.01142.x

1399-3046

Rebecca G. Carey, John C. Bucuvalas, William F. Balistreri, Todd G. Nick, Frederick R. Ryckman, Nada Yazigi,

Organ Transplantation Techniques and Outcomes

Carey RG, Bucuvalas JC, Balistreri WF, Nick TG, Ryckman FR, Yazigi N. Hyponatremia increases mortality in pediatric patients listed for liver transplantation.Pediatr Transplantation 2010: 14: 115–120. © 2009 John Wiley & Sons A/S. Abstract: To evaluate hyponatremia as an independent predictor of mortality in pediatric patients with end-stage liver disease listed for transplantation. We performed a single-center retrospective study of children listed for liver transplantation. We defined hyponatremia as a serum sodium concentration 130 mEq/L (p < 0.001). Univariable association analyses demonstrated death on the waiting list was also associated with higher median PELD scores at listing (p = 0.01), non-white race (p = 0.02), and age <1 yr (p = 0.001). Logistic regression analysis identified hyponatremia and non-white race as independently associated with pretransplant mortality [OR = 8.0 (95% CI: 1.4–45.7), p = 0.02 and OR = 6.3 (95% CI: 1.25–33.3), p = 0.03]. When hyponatremia was added to the PELD score, it was significantly better in predicting mortality than the PELD score alone (c-statistic = 0.79, p = 0.03). Hyponatremia identifies a subset of pediatric patients with increased risk of pretransplant mortality and improves the predictive ability of the current PELD score.